2-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine → 2-(4-Iodo-imidazol-1-yl)-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine

HRID 906256Notes

Reaction equation

HRID 906256 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)[N:3]=1.[I:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1>>[I:19][C:20]1[N:21]=[CH:22][N:23]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=3)[N:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 866246342-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 673928852-(4-Iodo-imidazol-1-yl)-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine (example A.4) (0.27 g, 1.0 mmol) and commercially available 4-iodo-imidazole (0.21 g, 1.1 mmol) according to the general procedure Ia. Obtained as a light brown solid (0.35 g, 81%). MS (ISP) 432.1 [(M+H)+]; mp 193.5° C.

Sources & evidence

ORD record
ord-302944bcd2a14446bb3fdedf19d3b334
Source dataset
uspto-grants-2011_09
Patent number
US08012986B2

Reaction notes

Loading…