HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromophenyl)boronic acid → 2-(3-Bromo-phenyl)-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromophenyl)boronic acid | HCID 2734318 | — |
| Reactant | 2-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine | HCID 86624634 | — |
| Product | 2-(3-Bromo-phenyl)-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine | HCID 67393013 | — |
Reaction Steps
The title compound was prepared from 2-chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine (example A.4) (0.41 g, 1.5 mmol) and commercially available 3-bromo-benzene-boronic acid (0.33 g, 1.64 mmol) according to the general procedure IIb. Obtained as a light yellow solid (0.30 g, 51%). MS (ISP) 394.0 [(M+H)+]; mp 130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012986B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-012836ec119c44c394f72502a28a8be3 |
| Source note | uspto-grants-2011_09 |