(3-Bromophenyl)boronic acid → 6'-(3-Bromo-phenyl)-2'-methyl-6-trifluoromethyl-[3,4']bipyridinyl

HRID 906259Notes

Reaction equation

HRID 906259 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](OS(C(F)(F)F)(=O)=O)[CH:5]=[C:4]([C:16]2[CH:17]=[N:18][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:21]=2)[CH:3]=1.[Br:26][C:27]1[CH:28]=[C:29](B(O)O)[CH:30]=[CH:31][CH:32]=1>>[Br:26][C:27]1[CH:28]=[C:29]([C:6]2[N:7]=[C:2]([CH3:1])[CH:3]=[C:4]([C:16]3[CH:17]=[N:18][C:19]([C:22]([F:24])([F:25])[F:23])=[CH:20][CH:21]=3)[CH:5]=2)[CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 86624636HCID 86624636, compound

Product 1

HCID 673935546'-(3-Bromo-phenyl)-2'-methyl-6-trifluoromethyl-[3,4']bipyridinyl

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 6′-methyl-6-trifluoromethyl-[3,4′]bipyridinyl-2′-yl ester (example A.5) (0.773 g, 2.0 mmol) and commercially available 3-bromo-benzene-boronic acid (0.43 g, 2.1 mmol) according to the general procedure IIb. Obtained as a white solid (0.69 g, 88%). MS (ISP) 393.1 [(M+H)+] and 395.1 [(M+2+H)+].

Sources & evidence

ORD record
ord-396ed484b3bb4ac681d044f239142f9d
Source dataset
uspto-grants-2011_09
Patent number
US08012986B2

Reaction notes

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