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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9063Generated: October 26, 2026

Dimethylamine → [(5-Chloro-1H-indol-3-yl)-(2-fluoro-phenyl)-methyl]-dimethyl-amine

https://huagongshe.com/reaction/9063

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
Reactanto-FluorobenzaldehydeHCID 67970—
Reactant5-ChloroindoleHCID 87110—
Reactant(2-Fluoro-benzylidene)-dimethylammonium chlorideHCID 21985353—
Product[(5-Chloro-1H-indol-3-yl)-(2-fluoro-phenyl)-methyl]-dimethyl-amineHCID 21985292—

Reaction Steps

The preparation was carried out in accordance with general synthesis instructions 4 from 5-chloro-1H-indole and (2-fluoro-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 2-fluoro-benzaldehyde and dimethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091220B2
Source datasetuspto-grants-2006_08
ORD IDord-050cdd945ea044439f3df802c5f31ea6
Source noteuspto-grants-2006_08