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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906365Generated: October 30, 2026

Potassium Hydroxide → 1,1-Dimethylethyl (2R)-4-[(4-aminophenyl)methyl]-2-methyl-1-piperazinecarboxylate

https://huagongshe.com/reaction/906365

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant1,1-Dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylateHCID 59262157—
Product1,1-Dimethylethyl (2R)-4-[(4-aminophenyl)methyl]-2-methyl-1-piperazinecarboxylateHCID 59262164—

Reaction Steps

The title compound was prepared from 1,1-dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate (D24) using a method similar to that described for D22 in Description 22 although aqueous 2M KOH solution was used in place of solid KOH and the reaction time was 0.5 h. MS (ES): MH+ 306.2, MNa+ 328.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08012981B2
Source datasetuspto-grants-2011_09
ORD IDord-8e20c1f949974839979497248991738a
Source noteuspto-grants-2011_09