Sodium Acetate → HCID 57439897, compound

HRID 906410Notes

Reaction equation

HRID 906410 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][CH2:14][CH2:15]Cl)[CH:6]=[C:5]2[CH:17]=[O:18].[C:19]([O-:22])(=[O:21])[CH3:20].[Na+]>CS(C)=O.O>[C:19]([O:22][CH2:15][CH2:14][CH2:13][N:7]1[CH:6]=[C:5]([CH:17]=[O:18])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=2)[C:8]1=[O:12])(=[O:21])[CH3:20]

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 86640964HCID 86640964, compound

Product 1

HCID 57439897HCID 57439897, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A solution of 6-bromo-2-(3-chloropropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde (Example 10b, 0.90 g) in DMSO (10 mL) was treated with sodium acetate (0.45 g) under nitrogen. The resulting mixture was stirred at 70° C. for 10 h. The cooled reaction mixture was diluted with water (250 mL), and extracted with ethyl acetate (250 mL). The organic was dried (MgSO4), filtered and evaporated to afford subtitle compound. (0.91 g).

Workup

  1. customThe cooled reaction mixture
  2. extractionextracted with ethyl acetate (250 mL)
  3. dry with materialThe organic was dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-88a050e5d00d4732ad1c0a7bc6e53524
Source dataset
uspto-grants-2011_09
Patent number
US08012980B2

Reaction notes

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