HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906415Generated: October 26, 2026
Benzoyl Peroxide → 6-Bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one
https://huagongshe.com/reaction/906415
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-bromo-4-methyl-2-(phenylsulfonyl)isoquinolin-1(2H)-one | HCID 57439899 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 6-Bromo-4-(bromomethyl)-2-(phenylsulfonyl)isoquinolin-1(2H)-one | HCID 67130330 | 61.8% |
Reaction Steps
A solution of 6-bromo-4-methyl-2-(phenylsulfonyl)isoquinolin-1(2H)-one (Example 11c, 4.55 g) in benzene (40 mL) was treated with N-bromosuccinimide (3.00 g) and benzoyl peroxide (0.291 g) under nitrogen. The resulting solution was heated at 80° C. for 3 h. The cooled reaction mixture was evaporated to dryness. Purification (SiO2 chromatography, elution with 60% DCM in isohexane) afforded the subtitle compound (3.40 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012980B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-b8345cd40ae14166a5588aa5a0c7a182 |
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| Source note | uspto-grants-2011_09 |
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