HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 6-Bromo-2-(3-hydroxy-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 6-Bromo-2-(3-chloro-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde | HCID 86640961 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-Bromo-2-(3-hydroxy-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde | HCID 86640968 | — |
Reaction Steps
A solution of 6-bromo-2-(3-chloro-2,2-dimethylpropyl)-1-oxo-1,2-dihydroisoquinoline-4-carbaldehyde (Example 26c, 20 g) in DMSO (140 mL) was treated with sodium acetate (55 g) under nitrogen. The resulting mixture was stirred at 135° C. for 48 h during which more sodium acetate was added after 6 h (55 g), 24 h (55 g) then 30 h (22.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012980B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-4f9145a0ce324abd8c91727f764cfa17 |
| Source note | uspto-grants-2011_09 |