Methanesulfonyl chloride → N-Cyclopropyl-3-fluoro-5-[2-(3-hydroxy-2,2-dimethylpropyl)-4-{[(3S)-3-methylpiperazin-1-yl]methyl}-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide hydrochloride

Participants

Reaction Steps

The subtitle product was made from 3-[2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-4-(hydroxymethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide (Example 26 g, 190 mg) by sequential reaction with methanesulfonyl chloride (57 μL) and tert-butyl (2S)-2-methylpiperazine-1-carboxylate (240 mg) using a similar method to Example 26 h, to afford the title compound (58 mg) as a white solid.

Provenance & Evidence