Ethanol → HCID 45256713, compound

Participants

Reaction Steps

A solution of tert-butyl 4-(1-{2-(3-{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-1-oxo-1,2-dihydroisoquinolin-4-yl}ethyl)piperazine-1-carboxylate (Example 38c, 80 mg) in 4 M HCl in dioxane (1 mL) and ethanol (3 mL) was stirred overnight at room temperature before the volatiles were removed in vacuo. The crude material was dissolved in methanol (2 mL) and loaded onto a 10 g SCX cartridge. The impurities were washed through with methanol (50 mL) and discarded. The product was eluted with 1 N methanolic ammonia (50 mL) and evaporated in vacuo to afford the title product (58 mg).

Provenance & Evidence