Potassium Carbonate → HCID 67390832, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-{[6-bromo-2-(cyclopropylmethyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]sulfonyl}piperazine-1-carboxylate (Example 47b, 0.890 g) in DMF (10 mL) was treated with N-cyclopropyl-3-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzamide (0.491 g), Pd-118 (0.030 g) and potassium carbonate (0.425 g). The mixture was stirred at 70° C. for 1 h. The cooled reaction mixture was diluted with water (100 mL), and extracted into ethyl acetate (3×100 mL). The combined organic extracts were washed with brine (3×100 mL), dried (MgSO4), filtered and evaporated. The crude product was purified (SiO2 chromatography, elution with 10% ethyl acetate/DCM) to afford the subtitle compound (0.713 g) as beige foam, which was used without further analysis.

Provenance & Evidence