HRID906465

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCC1(COS(C)(=O)=O)CC1

HCID59000927

Cyclopropanemethanol, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-, 1-methanesulfonate

C12H26O4SSi

结构：CC(C)(C)OC(=O)N1CCC[C@H](CSc2c[nH]c(=O)c3ccc(Br)cc23)C1

HCID86640976

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC[C@H](CSc2cn(CC3(CO[Si](C)(C)C(C)(C)C)CC3)c(=O)c3ccc(Br)cc23)C1

HCID86640975

未命名化合物

收率 40.3%

PROCEDURE

实验过程

tert-Butyl (3S)-3-{[(6-bromo-1-oxo-1,2-dihydroisoquinolin-4-yl)sulfanyl]methyl}-piperidine-1-carboxylate (Example 63c, 190 mg) was reacted with [1-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopropyl]methyl methanesulfonate (136 mg) by the method of Example 58c to afford the subtitle compound (110 mg) as a colourless oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-60c938acf22f409792899d85c63eaf51
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08012980B2
来源说明: uspto-grants-2011_09

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[S:13][CH2:14][C@H:15]1[CH2:20][CH2:19][CH2:18][N:17]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:16]1.CS(O[CH2:33][C:34]1([CH2:37][O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:36][CH2:35]1)(=O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:33][C:34]1([CH2:37][O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:35][CH2:36]1)[CH:6]=[C:5]2[S:13][CH2:14][C@H:15]1[CH2:20][CH2:19][CH2:18][N:17]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:16]1