HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906477Generated: October 25, 2026
Acetic Anhydride → N,5-Dimethyl-1H-indol-2-amine dihydrochloride
https://huagongshe.com/reaction/906477
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N,5-Dimethyl-1H-indol-2-amine dihydrochloride | HCID 57435942 | — |
Reaction Steps
5 g of 1-(4-methylphenyl)hydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness. The precipitate formed is dissolved in 30 ml of ether and then a solution of 4.6 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the precipitate formed is filtered off to produce 3 g of the expected compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08012991B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-6195c2f4d6214f1797b9bf9cb9dd21bb |
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| Source note | uspto-grants-2011_09 |
|---|
