참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | Propanoyl chloride, 3-bromo- | HCID 84944 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(4-Methylphenyl)pyrazolidin-3-one | HCID 1913485 | 19,455.801% |
반응 단계
10 g of p-tolylhydrazine hydrochloride are dissolved in 100 ml of anhydrous CH2Cl2. The solution is cooled to 0° C. and 19 ml of DBU and then 6.5 mg of 3-bromopropionyl chloride are added. The mixture is stirred at ambient temperature for one hour. The reaction medium is poured onto water, extraction is carried out with CH2Cl2 and then purification is carried out by chromatography on a silica column eluted with an AcOEt/petroleum ether (v/v; 50/50) mixture. 1.3 g of crystals are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08012991B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-af986a9ec0764771a06819006f7a150d |
|---|
| 출처 메모 | uspto-grants-2011_09 |
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