HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906490Generated: October 30, 2026
Phosphorus tribromide → 5-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole
https://huagongshe.com/reaction/906490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (6-Chloro-1,3-benzodioxol-5-yl)methanol | HCID 7015319 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole | HCID 19105299 | — |
Reaction Steps
2.5 g of 6-chloropiperonyl alcohol are dissolved in 80 ml of ethyl ether. The solution is cooled to 0° C. and then 1.9 ml of PBr3 are added. The mixture is stirred at ambient temperature for 18 hours. It is poured onto ice and then extraction is carried out with AcOEt. The organic phase is washed with a saturated NaCl solution. 3.3 g of powder are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012991B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-758596f7645c4ff1b89bab180b65290d |
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| Source note | uspto-grants-2011_09 |
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