HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-(3-Hydroxymethylphenyl)-1,6-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1,6-Dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]-indol-3-yl)benzaldehyde | HCID 86602343 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(3-Hydroxymethylphenyl)-1,6-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one | HCID 67387052 | 71% |
Reaction Steps
280 mg of the compound obtained in Stage A are placed in 10 ml of CH2Cl2 and the minimum amount of AcOH to dissolve the compound, 375 mg of NaBH(OAc)3 are added and then the mixture is left stirring at AT for 18 hours. The reaction medium is evaporated and the residue is taken up in AcOEt and then filtration is carried out to produce 200 mg of the expected compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012991B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ef29adcf0c224b079b624b7ad199e8ec |
| Source note | uspto-grants-2011_09 |