HCID 59164513, compound → HCID 59164427, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-acetylamino-4-hydroxymethyl-benzoic acid methyl ester (1.7 g, 7.62 mmol) in DCM (40 mL) was added MnO2 (1.32 g, 2 equiv) and the resulting mixture was stirred at 50° C. for 18 h. MnO2 (0.66 g, 1 equiv) was added and the mixture was stirred at 50° C. for 2 h. The mixture was cooled down, filtered through a pad of celite and washed with DCM. The solvent was removed in vacuo to afford a crude yellow solid. The residue was purified by flash chromatography (silica gel, EtOAc/hexanes (0:100 to 50:50)) to provide the title compound as a light yellow solid (1.15 g, 68%) (ES-MS: m/z 263.2 [M+CH3CN+H]+, rt 4.29 min).

Provenance & Evidence