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HRID906876

反应详情

EQUATION

反应方程式

HRID 906876 反应方程式

REACTANTS

反应物

4
Methanol 分子结构式
HCID887

Methanol

CH4O

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl 分子结构式
HCID634876

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl

C44H32P2

3-Chloro-4-fluorophenylboronic acid 分子结构式
HCID2734660

3-Chloro-4-fluorophenylboronic acid

C6H5BClFO2

HCID 57576371 分子结构式
HCID57576371

未命名化合物

PRODUCTS

产物

1
HCID 67131400 分子结构式
HCID67131400

未命名化合物

收率 22%

AUXILIARIES

试剂、催化剂与溶剂

1
Water 分子结构式
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

A two necked flask was charged under argon with rhodium(acac)bis ethylene (31 mg, 0.05 eq.), (R)-BINAP (76 mg, 0.05 eq.) and 3-chloro-4-fluoro-phenylboronic acid (850 mg, 2.0 eq.). 60 mL of MeOH and 6.0 mL of H2O were added followed by 1-(1-benzyl-2,5-dihydro-1H-pyrrol-3-yl)-ethanone. The reaction mixture was heated at 60° C. for 2 hours, cooled down to RT and concentrated under vacuo. Purification by flash chromatography (SiO2, EtOAc/Heptane 2/1) afforded 180 mg (22%) of the title product as a light yellow oil.

WORKUP

后处理

  1. temperaturecooled down to RT
  2. concentrationconcentrated under vacuo
  3. customPurification by flash chromatography (SiO2, EtOAc/Heptane 2/1)