Diisopropylethylamine → HCID 57576361, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-{(S)-1-[(3R,4S)-1-benzyl-4-(3-chloro-4-fluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-nicotinonitrile-48 mg (0.11 mmol) dissolved in toluene (1 mL) were added 47 mg (0.33 mmol) of 1-chloroethyl chloroformate and 43 mg (0.33 mmol) of Hunig's base. The reaction mixture was heated at 100° C. for one hour. After cooling down to RT, volatiles were removed under vacuo and the crude was dissolved in MeOH (5 mL). The reaction mixture was heated at 85° C. for 30 minutes and after cooling down to RT, volatiles were removed under vacuo and the residue was directly purified on column chromatography (SiO2, CH2Cl2/MeOH 9:1) yielded 28 mg (72%) of the title compound as a light yellow oil. ES-MS m/e: 346.1 (M+H+).

Provenance & Evidence