HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 6-((Dimethylamino)methyl)-3-pyridinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 6-(Bromomethyl)-3-pyridinecarboxylic acid | HCID 21840978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ammonia | HCID 222 | 1% |
| Product | 6-((Dimethylamino)methyl)-3-pyridinecarboxylic acid | HCID 57573745 | 70% |
Reaction Steps
2nd step: To a stirred solution of 6-bromomethyl-nicotinic acid (350 mg, 1.62 mmol) in EtOH (3 mL) was added a solution of dimethyl-amine in EtOH (2 mL, 30% solution). Stirring was continued for 1 hour, concentrated under vacuo. Column chromatography (SiO2, CH2Cl2/MeOH: 8/2, aq. NH3 1%) yielded 205 mg (70%) of 6-dimethylaminomethyl-nicotinic acid as a light brown solid. ES-MS m/e: 181.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012998B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e3254bb8d29d4baaaaec976878d6975a |
| Source note | uspto-grants-2011_09 |