HCID 67131675, compound → HCID 67415143, compound

HRID 906944Notes

Reaction equation

HRID 906944 reaction equation
[CH2:1]([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[CH:14]=2)[C@@H:10]([C@H:21]([OH:31])[CH2:22][O:23][Si:24]([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:32][C:33]1[CH:34]=[CH:35][C:36](O)=[N:37][CH:38]=1>>[CH2:1]([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[CH:14]=2)[C@@H:10]([C@@H:21]([O:31][C:36]2[CH:35]=[CH:34][C:33]([Cl:32])=[CH:38][N:37]=2)[CH2:22][O:23][Si:24]([C:27]([CH3:28])([CH3:30])[CH3:29])([CH3:26])[CH3:25])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67131675HCID 67131675, compoundHCID 1785160645-chloropyridin-2-ol

Product 1

HCID 67415143HCID 67415143, compound

Procedure

The titled compound was prepared following the general procedure for Mitsunobu reaction using (S)-1-[(3R,4S)-1-benzyl-4-(3,4-difluoro-phenyl)-pyrrolidin-3-yl]-2-(tert-butyl-dimethyl-silanyloxy)-ethanol and 5-Chloro-pyridin-2-ol. ES-MS m/e: 559.2 (M+H+).

Workup

  1. customfor Mitsunobu reaction

Sources & evidence

ORD record
ord-83b1cbc8a89b4957af92a9966e8ef6ff
Source dataset
uspto-grants-2011_09
Patent number
US08012998B2

Reaction notes

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