6-Methyl-4-pyridazinecarboxylic acid hydrochloride → [(3R,4S)-3-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(5-chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-difluoro-phenyl)-pyrrolidin-1-yl]-(6-methyl-pyridazin-4-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	6-Methyl-4-pyridazinecarboxylic acid hydrochloride	HCID 55300768	—
Reactant	2-{(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(3R,4S)-4-(3,4-difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-5-chloro-pyridine	HCID 67131828	—
Product	[(3R,4S)-3-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(5-chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-difluoro-phenyl)-pyrrolidin-1-yl]-(6-methyl-pyridazin-4-yl)-methanone	HCID 67131615	—

Reaction Steps

The titled compound was prepared following a general procedure I for amidation between 2-{(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(3R,4S)-4-(3,4-difluoro-phenyl)-pyrrolidin-3-yl]-ethoxy}-5-chloro-pyridine and 6-Methyl-pyridazine-4-carboxylic acid . ES-MS m/e: 589.1 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08012998B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-a113d735843947b3b37a77d07ca58f46
Source note	uspto-grants-2011_09