HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cerium(III) chloride → benzyl (2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cerium(III) chloride | HCID 24636 | — |
| Reactant | benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate | HCID 59556933 | — |
| Reactant | HCID 178420656 | HCID 178420656 | — |
| Product | benzyl (2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidine-1-carboxylate | HCID 59273057 | — |
Reaction Steps
By an operation in the same manner as in Reference Example 3 and using cerium chloride (12.9 g), 2 mol/L propylmagnesium bromide—THF solution (20 mL) and benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate (3.5 g), the title compound was obtained as pale-yellow oil (yield: 2.32 g, yield: 56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ac706bc776ae40cc827a813cdf876cfb |
| Source note | uspto-grants-2011_09 |