HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59273049, compound → (2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59273049 | HCID 59273049 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol | HCID 59273044 | — |
Reaction Steps
By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidine-1-carboxylate (1.05 g) and 50% water containing-10% Pd/C (0.05 g), the title compound was obtained as a colorless solid (yield: 0.65 g, yield: 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9b20bdabfe60473183b437d76f1b2928 |
| Source note | uspto-grants-2011_09 |