HCID 59273084, compound → (2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

HRID 906961Notes

Reaction equation

HRID 906961 reaction equation
[OH:1][C@@:2]1([CH3:20])[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[C@H:3]1[CH:17]([CH3:19])[CH3:18]>O>[CH:17]([C@H:3]1[C@@:2]([CH3:20])([OH:1])[CH2:6][CH2:5][NH:4]1)([CH3:19])[CH3:18]

Participants

3

Reactant 1

HCID 59273084HCID 59273084, compound

Product 1

HCID 59273040(2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate (1.78 g) and 50% water containing −10% Pd/C (0.09 g), the title compound was obtained as a colorless solid (yield: 1.07 g, yield: 89%).

Sources & evidence

ORD record
ord-ef38d6cc78fc4ae899931dfecc2f47c7
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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