HCID 59273074, compound → (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol

HRID 906963Notes

Reaction equation

HRID 906963 reaction equation
[CH2:1]([C@:3]1([OH:21])[CH2:7][CH2:6][N:5](C(OCC2C=CC=CC=2)=O)[C@H:4]1[CH:18]([CH3:20])[CH3:19])[CH3:2]>[Pd].O>[CH2:1]([C@:3]1([OH:21])[CH2:7][CH2:6][NH:5][C@H:4]1[CH:18]([CH3:20])[CH3:19])[CH3:2]

Participants

4

Reactant 1

HCID 59273074HCID 59273074, compound

Product 1

HCID 59273069(2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidine-1-carboxylate (2.2 g) and 50% water containing-10% Pd/C (0.11 g), the title compound was obtained as a colorless solid (yield: 1.33 g, yield: 83%).

Sources & evidence

ORD record
ord-d832021d577e4c1d8f5def85e928b879
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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