HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cerium(III) chloride → benzyl (2S,3R)-3-cyclopropyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cerium(III) chloride | HCID 24636 | — |
| Reactant | benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate | HCID 59556933 | — |
| Reactant | HCID 178420628 | HCID 178420628 | — |
| Product | benzyl (2S,3R)-3-cyclopropyl-3-hydroxy-2-methylpyrrolidine-1-carboxylate | HCID 59273039 | — |
Reaction Steps
By an operation in the same manner as in Reference Example 3 and using cerium chloride (11.1 g), 0.5 mol/L cyclopropylmagnesium bromide—THF solution (72.0 mL) and benzyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate (3.0 g), the title compound was obtained as colorless oil (yield: 1.64 g, yield: 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-6286d3c951bb4a45a33ba6c2a8cfca17 |
| Source note | uspto-grants-2011_09 |