HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cerium(III) chloride → tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cerium(III) chloride | HCID 24636 | — |
| Reactant | tert-butyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate | HCID 59273045 | — |
| Reactant | HCID 178420667 | HCID 178420667 | — |
| Product | tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate | HCID 59273002 | — |
Reaction Steps
By an operation in the same manner as in Reference Example 3 and using cerium chloride (3.95 g), 1 mol/L vinylmagnesium bromide—THF solution (12.5 mL) and tert-butyl (2S)-2-methyl-3-oxopyrrolidine-1-carboxylate (1.0 g), the title compound was obtained as colorless oil (yield: 0.648 g, yield: 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-5535c92f906c4518b175072ebc2ecd59 |
| Source note | uspto-grants-2011_09 |