Cerium(III) chloride → HCID 59273087, compound

HRID 906968Notes

Reaction equation

HRID 906968 reaction equation
[Cl-].[Ce+3].[Cl-].[Cl-].C[Mg]Br.[CH2:8](OCC)C.[CH2:13]([C@H:15]1[C:19](=[O:20])[CH2:18][CH2:17][N:16]1[C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])[CH3:14]>>[CH2:13]([C@H:15]1[C@:19]([OH:20])([CH3:8])[CH2:18][CH2:17][N:16]1[C:21]([O:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])[CH3:14]

Participants

4

Reactant 3

HCID 24636Cerium(III) chlorideHCID 59273038benzyl (2S)-2-ethyl-3-oxopyrrolidine-1-carboxylateHCID 178467822HCID 178467822, compound

Product 1

HCID 59273087HCID 59273087, compound

Procedure

By an operation in the same manner as in Reference Example 3 and using cerium chloride (11.69 g), 3 mol/L methylmagnesium bromide-diethyl ether solution (13.55 mL) and benzyl (2S)-2-ethyl-3-oxopyrrolidine-1-carboxylate (3.35 g), the title compound was obtained as colorless oil (yield: 2.84 g, yield: 84%).

Sources & evidence

ORD record
ord-347ee20f605f44c2a765c9628ddf6ea1
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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