HCID 59273087, compound → (2S,3S)-2-ethyl-3-methylpyrrolidin-3-ol

HRID 906969Notes

Reaction equation

HRID 906969 reaction equation
[CH2:1]([C@H:3]1[C@:7]([OH:9])([CH3:8])[CH2:6][CH2:5][N:4]1C(OCC1C=CC=CC=1)=O)[CH3:2]>[Pd].O>[CH2:1]([C@H:3]1[C@@:7]([CH3:8])([OH:9])[CH2:6][CH2:5][NH:4]1)[CH3:2]

Participants

4

Reactant 1

HCID 59273087HCID 59273087, compound

Product 1

HCID 59273072(2S,3S)-2-ethyl-3-methylpyrrolidin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-2-ethyl-3-hydroxy-3-methylpyrrolidine-1-carboxylate (2.84 g) and 50% water containing-10% Pd/C (0.31 g), the title compound was obtained as a colorless solid (yield: 1.77 g, yield: 88%).

Sources & evidence

ORD record
ord-ec331906123d4de4b4cb71e3626540d9
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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