Cerium(III) chloride → HCID 59273015, compound

HRID 906970Notes

Reaction equation

HRID 906970 reaction equation
[Cl-].[Ce+3].[Cl-].[Cl-].[CH2:5]([Mg]Br)[CH3:6].C(OCC)C.[CH2:14]([C@H:16]1[C:20](=[O:21])[CH2:19][CH2:18][N:17]1[C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[CH3:15]>>[CH2:14]([C@H:16]1[C@@:20]([CH2:5][CH3:6])([OH:21])[CH2:19][CH2:18][N:17]1[C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[CH3:15]

Participants

4

Reactant 3

HCID 24636Cerium(III) chlorideHCID 59273038benzyl (2S)-2-ethyl-3-oxopyrrolidine-1-carboxylateHCID 178467792HCID 178467792, compound

Product 1

HCID 59273015HCID 59273015, compound

Procedure

By an operation in the same manner as in Reference Example 3 and using cerium chloride (8.58 g), 3 mol/L ethylmagnesium bromide—diethyl ether solution (9.6 mL) and benzyl (2S)-2-ethyl-3-oxopyrrolidine-1-carboxylate (2.37 g), the title compound was obtained as colorless oil (yield: 2.19 g, yield: 82%).

Sources & evidence

ORD record
ord-af01422d36274be8be695fccfad61495
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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