HCID 59273015, compound → HCID 59273053, compound

HRID 906971Notes

Reaction equation

HRID 906971 reaction equation
[CH2:1]([C@H:3]1[C@@:7]([CH2:9][CH3:10])([OH:8])[CH2:6][CH2:5][N:4]1C(OCC1C=CC=CC=1)=O)[CH3:2]>[Pd].O>[CH2:1]([C@H:3]1[C@@:7]([CH2:9][CH3:10])([OH:8])[CH2:6][CH2:5][NH:4]1)[CH3:2]

Participants

4

Reactant 1

HCID 59273015HCID 59273015, compound

Product 1

HCID 59273053HCID 59273053, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-2,3-diethyl-3-hydroxypyrrolidine-1-carboxylate (2.19 g) and 50% water containing-10% Pd/C (0.22 g), the title compound was obtained as a colorless solid (yield: 1.40 g, yield: 94%).

Sources & evidence

ORD record
ord-4005acefdc934ef3a268daf86ecc2ee5
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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