HCID 59273035, compound → (2S,3R)-3-cyclopropyl-2-ethylpyrrolidin-3-ol

HRID 906973Notes

Reaction equation

HRID 906973 reaction equation
[CH:1]1([C@:4]2([OH:21])[CH2:8][CH2:7][N:6](C(OCC3C=CC=CC=3)=O)[C@H:5]2[CH2:19][CH3:20])[CH2:3][CH2:2]1>[Pd].O>[CH:1]1([C@:4]2([OH:21])[CH2:8][CH2:7][NH:6][C@H:5]2[CH2:19][CH3:20])[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 59273035HCID 59273035, compound

Product 1

HCID 59273036(2S,3R)-3-cyclopropyl-2-ethylpyrrolidin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3R)-3-cyclopropyl-2-ethyl-3-hydroxypyrrolidine-1-carboxylate (2.01 g) and 50% water containing-10% Pd/C (0.20 g), the title compound was obtained as a colorless solid (yield: 1.35 g, yield: 96%).

Sources & evidence

ORD record
ord-48273e646f5e4254adbad3d003064ed4
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

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