Methyl morpholine oxide → HCID 59273060, compound

Participants

Reaction Steps

To a solution (20 mL) of benzyl (2S,3S,5R)-3-hydroxy-2,5-dimethylpyrrolidine-1-carboxylate (1.30 g) in acetonitrile were added tetrapropylammonium perruthenate (92 mg), 4-methylmorpholine N-oxide (1.22 g) and molecular sieves 4A powder (1.32 g), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, the residue was suspended in ethyl acetate and filtered through celite. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=30/1→1/1) to give the title compound as colorless oil (yield: 1.30 g, yield: 100%).

Provenance & Evidence