HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 4-Fluoro-2-methoxybenzonitrile | HCID 2783329 | — |
| Reactant | (2S,3S)-2,3-dimethylpyrrolidin-3-ol | HCID 59556870 | — |
| Product | 4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-2-methoxybenzonitrile | HCID 59273086 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-dimethylpyrrolidin-3-ol 0.5 oxalate (228 mg), 4-fluoro-2-methoxybenzonitrile (317 mg) and lithium carbonate (206 mg), the title compound was obtained as a colorless solid (yield: 170 mg, yield: 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-df6683d38d5c4467afd2ac73ad46b1d0 |
| Source note | uspto-grants-2011_09 |