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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906989Generated: October 30, 2026

Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-3-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/906989

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium CarbonateHCID 11125—
Reactant4-Fluoro-3-(trifluoromethyl)benzonitrileHCID 144255—
Reactant(2S,3S)-3-ethyl-2-methylpyrrolidin-3-olHCID 59273028—
Product4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-3-(trifluoromethyl)benzonitrileHCID 59273088—

Reaction Steps

By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol 0.5 oxalate (257 mg), 4-fluoro-3-(trifluoromethyl)benzonitrile (419 mg) and lithium carbonate (218 mg), the title compound was obtained as colorless oil (yield: 218 mg, yield: 49%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08013008B2
Source datasetuspto-grants-2011_09
ORD IDord-030e99dbec1640f6aac2626eb6d75b95
Source noteuspto-grants-2011_09