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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 906990Generated: October 31, 2026

Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrile

https://huagongshe.com/reaction/906990

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium CarbonateHCID 11125—
Reactant2,4-Difluoro-3-methylbenzonitrileHCID 11344119—
Reactant(2S,3S)-3-ethyl-2-methylpyrrolidin-3-olHCID 59273028—
Product4-[(2S,3S)-3-ethyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrileHCID 59273073—

Reaction Steps

By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-methylpyrrolidin-3-ol 0.5 oxalate (257 mg), 2,4-difluoro-3-methylbenzonitrile (340 mg) and lithium carbonate (218 mg), the title compound was obtained as colorless oil (yield: 184 mg, yield: 47%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08013008B2
Source datasetuspto-grants-2011_09
ORD IDord-10804e0f4c54408780fab98ff1dd0822
Source noteuspto-grants-2011_09