HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-fluoro-4-[(2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidin-1-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2,4-Difluorobenzonitrile | HCID 77545 | — |
| Reactant | (2S,3S)-2-methyl-3-propylpyrrolidin-3-ol | HCID 59273025 | — |
| Product | 2-fluoro-4-[(2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidin-1-yl]benzonitrile | HCID 59273004 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-2-methyl-3-propylpyrrolidin-3-ol 0.5 oxalate (250 mg), 2,4-difluorobenzonitrile (367 mg) and lithium carbonate (195 mg), the title compound was obtained as colorless oil (yield: 287 mg, yield: 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-a41eb04277cd46499f80cd2c5116282e |
| Source note | uspto-grants-2011_09 |