HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2,6-difluoro-4-[(2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidin-1-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2,4,6-Trifluorobenzonitrile | HCID 737177 | — |
| Reactant | (2S,3S)-2-methyl-3-propylpyrrolidin-3-ol | HCID 59273025 | — |
| Product | 2,6-difluoro-4-[(2S,3S)-3-hydroxy-2-methyl-3-propylpyrrolidin-1-yl]benzonitrile | HCID 59273009 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-2-methyl-3-propylpyrrolidin-3-ol 0.5 oxalate (250 mg), 2,4,6-trifluorobenzonitrile (414 mg) and lithium carbonate (195 mg), the title compound was obtained as colorless oil (yield: 233 mg, yield: 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-50136fd17db64c59b6399432c6387acc |
| Source note | uspto-grants-2011_09 |