HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2-Chloro-4-fluoro-3-methylbenzonitrile | HCID 44550971 | — |
| Reactant | (2S,3S)-2-methyl-3-propylpyrrolidin-3-ol | HCID 59273025 | — |
| Product | 2-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile | HCID 59273018 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-2,3-dimethylpyrrolidin-3-ol 0.5 oxalate (260 mg), 2-chloro-4-fluoro-3-methylbenzonitrile (550 mg) and lithium carbonate (240 mg), the title compound was obtained as a colorless solid (yield: 320 mg, yield: 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-825260c3ebbc447c9a7022a05ea741b2 |
| Source note | uspto-grants-2011_09 |