HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidin-1-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2-Chloro-4-fluorobenzonitrile | HCID 109000 | — |
| Reactant | (2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol | HCID 59273044 | — |
| Product | 2-chloro-4-[(2S,3S)-3-hydroxy-2-methyl-3-(trifluoromethyl)pyrrolidin-1-yl]benzonitrile | HCID 24986665 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-2-methyl-3-(trifluoromethyl)pyrrolidin-3-ol 0.5 oxalate (200 mg), 2-chloro-4-fluorobenzonitrile (289 mg) and lithium carbonate (138 mg), the title compound was obtained as a colorless solid (yield: 100 mg, yield: 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e3a5b0b8c784422ebdc5973ada1a0d4c |
| Source note | uspto-grants-2011_09 |