HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2,6-difluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2,4,6-Trifluorobenzonitrile | HCID 737177 | — |
| Reactant | (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol | HCID 59273069 | — |
| Product | 4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2,6-difluorobenzonitrile | HCID 59273046 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (203 mg), 2,4,6-trifluorobenzonitrile (157 mg) and lithium carbonate (163 mg), the title compound was obtained as colorless oil (yield: 143 mg, yield: 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-400defa4579944f6b550a48df8c247f8 |
| Source note | uspto-grants-2011_09 |