HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 4-Fluoro-2-methoxybenzonitrile | HCID 2783329 | — |
| Reactant | (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol | HCID 59273069 | — |
| Product | 4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-methoxybenzonitrile | HCID 59273054 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (203 mg), 4-fluoro-2-methoxybenzonitrile (151 mg) and lithium carbonate (163 mg), the title compound was obtained as colorless oil (yield: 22 mg, yield: 7.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-2b4d2d2cbd274e638041d10b4080dd31 |
| Source note | uspto-grants-2011_09 |