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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 907001Generated: November 1, 2026

Lithium Carbonate → 4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/907001

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium CarbonateHCID 11125—
Reactant4-Fluoro-2-(trifluoromethyl)benzonitrileHCID 605085—
Reactant(2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-olHCID 59273069—
Product4-[(2S,3S)-3-ethyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrileHCID 59273007—

Reaction Steps

By an operation in the same manner as in Example 1 and using (2S,3S)-3-ethyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (203 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (189 mg) and lithium carbonate (163 mg), the title compound was obtained as colorless oil (yield: 180 mg, yield: 55%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08013008B2
Source datasetuspto-grants-2011_09
ORD IDord-eb76f0e313dc4c61847f96ca4346742d
Source noteuspto-grants-2011_09