HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 4-[(2S,3R)-3-cyclopropyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzonitrile | HCID 605085 | — |
| Reactant | (2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol | HCID 59273011 | — |
| Product | 4-[(2S,3R)-3-cyclopropyl-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile | HCID 59273051 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol 0.5 oxalate (215 mg), 4-fluoro-2-(trifluoromethyl)benzonitrile (189 mg) and lithium carbonate (163 mg), the title compound was obtained as a pale-brown solid (yield: 227 mg, yield: 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ce6a09c3f9514572bcd697b98f5a5422 |
| Source note | uspto-grants-2011_09 |