HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 4-[(2S,3R)-3-cyclopropyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2,4-Difluoro-3-methylbenzonitrile | HCID 11344119 | — |
| Reactant | (2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol | HCID 59273011 | — |
| Product | 4-[(2S,3R)-3-cyclopropyl-3-hydroxy-2-methylpyrrolidin-1-yl]-2-fluoro-3-methylbenzonitrile | HCID 59273077 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3R)-3-cyclopropyl-2-methylpyrrolidin-3-ol 0.5 oxalate (260 mg), 2,4-difluoro-3-methylbenzonitrile (364 mg) and lithium carbonate (234 mg), the title compound was obtained as a colorless solid (yield: 106 mg, yield: 24%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-4ea5448d353f47dcb66cbe757a047494 |
| Source note | uspto-grants-2011_09 |