HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate | HCID 59273002 | — |
| Product | (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol | HCID 67389951 | 306.2% |
Reaction Steps
To tert-butyl (2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidine-1-carboxylate (684 mg, 2.85 mmol) was added trifluoroacetic acid (3.0 ml). The mixture was stirred at room temperature for 15 min, and concentrated under reduced pressure to give (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol (yield: 1.11 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-aa41fda9d38d476cb44fa4e50a020064 |
| Source note | uspto-grants-2011_09 |