HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-fluoro-4-[(2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidin-1-yl]-3-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 2,4-Difluoro-3-methylbenzonitrile | HCID 11344119 | — |
| Reactant | (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol | HCID 67389951 | — |
| Product | 2-fluoro-4-[(2S,3R)-3-hydroxy-2-methyl-3-vinylpyrrolidin-1-yl]-3-methylbenzonitrile | HCID 59273052 | — |
Reaction Steps
By an operation in the same manner as in Example 1 and using (2S,3R)-2-methyl-3-vinylpyrrolidin-3-ol (556 mg), 2,4-difluoro-3-methylbenzonitrile (350 mg) and lithium carbonate (350 mg), the title compound was obtained as a colorless solid (yield: 84.6 mg, yield: 23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013008B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-c2ad25881c4e41edb7d21c0dd67ab8a5 |
| Source note | uspto-grants-2011_09 |