Lithium Carbonate → HCID 59273033, compound

HRID 907019Notes

Reaction equation

[CH:1]1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9]([CH3:11])C)CC1.F[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([O:22][CH3:23])[CH:15]=1.C(=O)([O-])[O-].[Li+].[Li+]>>[CH2:9]([C@H:5]1[C@:4]([OH:12])([CH3:1])[CH2:8][CH2:7][N:6]1[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([O:22][CH3:23])[CH:15]=1)[CH3:11]

Participants

Reactant 3

HCID 11125Lithium Carbonate

HCID 27833294-Fluoro-2-methoxybenzonitrile

HCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273033HCID 59273033, compound

Procedure

By an operation in the same manner as in Example 1 and using (2S,3S)-2-ethyl-3-methylpyrrolidin-3-ol 0.5 oxalate (210 mg), 4-fluoro-2-methoxybenzonitrile (320 mg) and lithium carbonate (210 mg), the title compound was obtained as a pale-yellow solid (yield: 195.8 mg, yield: 62%).

Sources & evidence

ORD record: ord-eb4a93441e334df49c35f17fb47e2657
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08013008B2

Reaction notes

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