Lithium Carbonate → HCID 59273032, compound

HRID 907034Notes

Reaction equation

HRID 907034 reaction equation
C1([C@:4]2([OH:12])[CH2:8][CH2:7][NH:6][C@H:5]2[CH:9](C)C)CC1.[Cl:13][C:14]1[CH:21]=[C:20](F)[CH:19]=[CH:18][C:15]=1[C:16]#[N:17].[C:23](=O)([O-])[O-].[Li+].[Li+]>>[Cl:13][C:14]1[CH:21]=[C:20]([N:6]2[C@H:7]([CH3:23])[CH2:8][C@H:4]([OH:12])[C@@H:5]2[CH3:9])[CH:19]=[CH:18][C:15]=1[C:16]#[N:17]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1090002-Chloro-4-fluorobenzonitrileHCID 59273011(2S,3R)-3-cyclopropyl-2-isopropylpyrrolidin-3-ol

Product 1

HCID 59273032HCID 59273032, compound

Procedure

By an operation in the same manner as in Example 53 and using (2S,3S,5R)-2,5-dimethylpyrrolidin-3-ol 0.5 oxalate (144 mg), 2-chloro-4-fluorobenzonitrile (254 mg) and lithium carbonate (193 mg), the title compound was obtained as colorless oil (yield: 61 mg, yield: 27%).

Sources & evidence

ORD record
ord-5f0cdea164f446dfafef72dc1ca7506a
Source dataset
uspto-grants-2011_09
Patent number
US08013008B2

Reaction notes

Loading…